NCT05306990

Statins in Patients With Type 2 Diabetes Mellitus and Previous History of Acute Coronary Syndrome

Efficacy and Safety of Atorvastatin 40mg Versus Rosuvastatin 20mg in Type II Diabetic Patients With Previous Acute Coronary Syndrome : Randomized Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 108 (actual)
• Sponsor: Helwan University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study was to compare the efficacy and safety of high dose atorvastatin (40 mg) versus high dose rosuvastatin (20 mg) in Egyptian type II diabetic patients with previous acute coronary syndrome history. This open-labeled prospective, randomized clinical trial compared once daily atorvastatin 40mg (Ator®) versus once daily rosuvastatin 20mg (Crestor®). The primary outcome was the 50% reduction in low-density lipoprotein cholesterol levels at 12 weeks. The secondary outcome was the achievement of low-density lipoprotein cholesterol level \< 55 mg/dl.

Conditions

• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Diabetes Mellitus

Interventions

Type	Name	Description
DRUG	Atorvastatin 40 Mg Oral Tablet	patients followed up for 3 months
DRUG	Rosuvastatin 20 Mg Oral Tablet	patients followed up for 3 months

Timeline

• Start date: 2017-04-20
• Primary completion: 2019-06-15
• Completion: 2021-01-31
• First posted: 2022-04-01
• Last updated: 2022-04-01

Locations

1 site across 1 country: Egypt