Trials / Recruiting
RecruitingNCT05306600
Onco-Genomas Brasil: Mapping Breast and Prostate Cancer in the Brazilian Public Health System
- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 882 (estimated)
- Sponsor
- Hospital Moinhos de Vento · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
This project aims to perform complete sequencing of the somatic (tumor) and germline exomes during clinical investigation of cancer patients treated through the Brazilian Unified Health System to generate genomic and phenotypic data for the Brazilian Ministry of Health's National Precision Genomics and Health Program, called Genomas Brasil, as well as to collect data on the population's ancestry.
Detailed description
In Brazil, the most frequent types of neoplasm are prostate cancer in men and breast cancer in women. Understanding the molecular variants in tumors, which result from mutations and variants that occur during carcinogenesis, can affect treatment response and disease prognosis and is an important target of oncology research. Detecting hereditary genetic syndromes also helps in oncological follow-up, allowing prediction of the risk of new neoplasms. This project aims to perform complete sequencing of the somatic (tumor) and germline exomes during clinical investigation of cancer patients treated through the Brazilian Unified Health System to generate genomic and phenotypic data for the Brazilian Ministry of Health's National Precision Genomics and Health Program, called Genomas Brasil, as well as to collect data on the population's ancestry.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | whole exome and whole genome sequencing analysis | Somatic and germline whole exome sequencing will be analyzed for prostate and HER2-positive breast cancer Somatic whole exome and germline whole genome sequencing will be analyzed for triple-negative breast cancer |
Timeline
- Start date
- 2022-11-09
- Primary completion
- 2026-12-31
- Completion
- 2026-12-31
- First posted
- 2022-04-01
- Last updated
- 2026-02-13
Locations
25 sites across 1 country: Brazil
Source: ClinicalTrials.gov record NCT05306600. Inclusion in this directory is not an endorsement.