NCT05304897

PRP Efficacy and Safety in BPF

Efficacy and Safety of Platelet-rich Plasma on Bronchopleural Fistula

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 16 (actual)
• Sponsor: Guangzhou Institute of Respiratory Disease · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Platelet-rich plasma(PRP), is a concentrate of platelet-rich plasma protein derived from whole blood. The main components of it are platelets, leukocytes and fibrin. Autologous PRP treatment can avoid the immune rejection caused by exogenous growth factor and the spread of disease. Evidence of the efficacy and safety of PRP has been proven in many studies. Bronchopleural fistula (BPF) represents a challenging clinical entity characterized by abnormal communication between the bronchial tree and the pleural space. Respiratory intervention has become one of the most common treatments to fight the disease. Although the short-term occlusion effect of conventional treatment methods of respiratory intervention is relatively easy to achieve, there is great uncertainty in the long-term treatment effect, and long-term large fistulas have little chance of healing. PRP has shown significant efficacy for hyperplastic scar of skin. Correspondingly, PRP will be applied as treatment of BPF to cure fistula.

Conditions

• Bronchopleural Fistula

Interventions

Type	Name	Description
PROCEDURE	PRP treatment	PRP treatment for bronchopleural fistula

Timeline

• Start date: 2022-04-16
• Primary completion: 2024-01-25
• Completion: 2024-01-25
• First posted: 2022-03-31
• Last updated: 2024-06-21

Locations

1 site across 1 country: China