NCT05304273

Comparison Between Letrozole and Mifepristone in Medical Termination of First Trimester Miscarriages

COMPARATIVE STUDY OF EFFECTS BETWEEN LETROZOLE PLUS MISOPROSTOL AND MIFEPRISTONE PLUS MISOPROSTOL IN TERMINATING NON-VIABLE FIRST TRIMESTER PREGNANCIES

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: Calcutta National Medical College and Hospital · Other Government
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

Prospective interventional study where participants with non-viable pregnancy at 1st trimester will be randomized into two arms, one group will receive conventional treatment with oral mifepristone followed by misoprostol vaginally and another group will receive letrozole for three consecutive days followed by misoprostol vaginally in an attempt to terminate the pregnancy medically. Mean duration of induction to expulsion of product of conception and rate of complete abortion will be compared in two groups.

Conditions

• Miscarriage

Interventions

Type	Name	Description
DRUG	Mifepristone	Participants with 1st trimester miscarriage will receive for medical termination
DRUG	Letrozole	Participants with 1st trimester miscarriage will receive for medical termination

Timeline

• Start date: 2022-05-05
• Primary completion: 2024-07-26
• Completion: 2024-10-01
• First posted: 2022-03-31
• Last updated: 2026-04-02

Locations

1 site across 1 country: India