NCT05303935

Effects of Quetiapine on Sleep and Next Day Alertness in People With Obstructive Sleep Apnea

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: Flinders University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Quetiapine is medication used to treat schizophrenia and bipolar disorder. Increasingly, low doses of quetiapine are prescribed "off-label" for insomnia. Quetiapine increases sleep duration with fewer interruptions, and people report feeling more rested. This accounts for why it is popular to prescribe for insomnia. Insomnia and obstructive sleep apnea (OSA) share many symptoms and differential diagnosis can be difficult. While quetiapine may improve sleep and breathing in certain people (i.e in light sleepers) an initial study indicated that quetiapine caused breathing disturbances in healthy individuals. Effects in OSA are unknown. In this placebo-controlled double blind study, participants with mild-moderate OSA will spend 2 nights in the sleep lab, one with quetiapine at a dose commonly prescribed for insomnia and one with placebo. The investigators will assess participants sleep by standard clinical sleep study, and morning alertness using questionnaires, reaction tests, and a driving simulator test.

Conditions

• Sleep Apnea, Obstructive

Interventions

Type	Name	Description
DRUG	Quetiapine 50 MG	A single dose of 50mg of quetiapine taken at bedtime for one night.
DRUG	Placebo	A placebo sugar pill that looks like the quetiapine tablet taken at bedtime for one night.

Timeline

• Start date: 2022-05-25
• Primary completion: 2023-04-04
• Completion: 2023-04-04
• First posted: 2022-03-31
• Last updated: 2023-07-06

Locations

1 site across 1 country: Australia