NCT05302206

Colonic Glucose vs. Saline Infusion

Colonic Glucose vs. Saline Infusion on Hormone Secretion and Glycemic Excursions

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (estimated)
• Sponsor: Qilu Hospital of Shandong University · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The distal ileum and proximal colon, where the glucagon-like peptide 1 (GLP-1) releasing cells predominate, are important organs in mediating glycemic control. The proximal colon is not easy to access and the correspond in vivo research remains to be difficult. The investigators intend to recruit subjects who underwent rectal surgery with simultaneous protective ileostomy and evaluate hormone secretion and glycemic excursions via ileostomy glucose or saline infusion, and quantify the glucose absorption rate within the proximal colon.

Conditions

• Gastrointestinal Hormones

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	colonic infusion	colonic glucose or colonic saline infusion

Timeline

• Start date: 2022-04-01
• Primary completion: 2022-07-01
• Completion: 2022-08-01
• First posted: 2022-03-31
• Last updated: 2022-03-31

Locations

1 site across 1 country: China