NCT05296863

Adipose-derived Stem Cell Conditioned Media as a Novel Approach for Hair Regrowth in Male Androgenetic Alopecia

Adipose-derived Stem Cell Conditioned Media as a Novel Approach for Hair Regrowth in Male Androgenetic Alopecia: A Randomized, Double-blind Clinical Trial

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 37 (actual)
• Sponsor: Dr. dr. Lili Legiawati, SpKK(K) · Academic / Other
• Sex: Male
• Age: 25 Years – 58 Years
• Healthy volunteers: Accepted

Summary

This study investigated the efficacy of adipose derived stem cell conditioned media (ADSC-CM) combined with minoxidil for hair regeneration therapy in male AGA.

Detailed description

This study was a double-blind, randomized clinical trial (RCT). Two concentrations of ADSC-CM were utilized: concentrated and non-concentrated ADSC-CM. The scalp was divided vertically in half; one side was injected with 2 ml of ADSC-CM, while the control side received 2 ml of NaCl 0,9%. After the injection, patients applied topical 5% minoxidil twice daily. Clinical improvements were assessed using photographic evaluation and trichoscan every two weeks.

Conditions

• Alopecia, Androgenetic
• Hair Loss/Baldness

Interventions

Type	Name	Description
COMBINATION_PRODUCT	Non-concentrated adipose-derived stem cell conditioned media and 5% Minoxidil	Non-concentrated ADSC-CM is given during week 0, 2, 4, and 6 on the left side of the scalp. Minoxidil is applied twice using a spray, in the morning and at night.
COMBINATION_PRODUCT	Concentrated adipose-derived stem cell conditioned media and 5% Minoxidil	Intervention is given during week 0, 2, 4, and 6 on the left side of the scalp. Minoxidil is applied twice using a spray, in the morning and at night.
COMBINATION_PRODUCT	Placebo and 5% Minoxidil	Intervention is given during week 0, 2, 4, and 6 on the right side of the scalp. Minoxidil is applied twice using a spray, in the morning and at night.

Timeline

• Start date: 2021-10-11
• Primary completion: 2021-12-03
• Completion: 2021-12-03
• First posted: 2022-03-25
• Last updated: 2022-03-25

Locations

1 site across 1 country: Indonesia