NCT05294978

EyeConic: Qualification for Cone-Optogenetics

Qualification for Cone-Optogenetics (EyeConic)

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 1,000 (estimated)
• Sponsor: Institute of Molecular and Clinical Ophthalmology Basel · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

This study aims to prepare for the first-in-human clinical trial of cone optogenetics vision restoration. As a first step, this worldwide multicenter ocular imaging study (EyeConic Study) is performed to identify eligible patients.

Detailed description

In a subset of patients with inherited retinal dystrophies (IRDs), cones lose their light-sensitive outer segments but remain alive in a dormant stage. This creates an opportunity to resensitize them through targeted optogenetic tools. However, the true proportion of low vision patients harboring dormant, non-functional cones, is currently unknown. The worldwide multicenter retrospective study (EyeConic) aims to estimate the proportion of low vision patients with remaining cone cell bodies for the first time.

Conditions

• Retinal Dystrophies

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Optical coherence tomography (OCT)	Data of macular optical coherence tomography (OCT)

Timeline

• Start date: 2021-07-01
• Primary completion: 2026-12-01
• Completion: 2026-12-01
• First posted: 2022-03-24
• Last updated: 2025-07-31

Locations

9 sites across 7 countries: United States, China, Germany, Hungary, Italy, Switzerland, United Kingdom