NCT05292378

Carbon Dioxide (CO2) and Cognitive Impairment

Carbon Dioxide (CO2): A Pilot Study of a Hypothesized Mechanism to Explain Cognitive Impairment

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 27 (actual)
• Sponsor: Rutgers, The State University of New Jersey · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The purpose of the study is to better understand the biological mechanisms of carbon dioxide (CO2)-induced cognitive impairments.

Detailed description

Participants will complete 2 study visits. Each study visit will consist of a 2.5-hour exposure session. Concentrations of CO2 during the exposure session will be either 600 ppm (control) or 2500 ppm (exposure). The order of the exposure sessions will be randomized and the exposure sessions will be at least one week apart. Up to two participants will take part in each exposure session. During each exposure a neurobehavioral assessment (Strategic Management Simulations or SMS) will be administered. Venous blood (30 mL) will be collected from subjects immediately before entering the chamber and immediately after the exposure. A subset of subjects (n=12) will also undergo a 60-minute fMRI scan. Another subset of subjects (up to 10) will not complete the SMS during the exposures but will undergo computer-assisted intravital microscopy (CAIM) to exam the conjunctival microvasculature before and after the exposure.

Conditions

• Healthy

Interventions

Type	Name	Description
OTHER	2500 ppm Carbon Dioxide	2.5 hour exposure to 2500 ppm carbon dioxide
OTHER	600 ppm Carbon Dioxide	2.5 hour exposure to 600 ppm carbon dioxide

Timeline

• Start date: 2022-07-14
• Primary completion: 2025-03-20
• Completion: 2025-03-20
• First posted: 2022-03-23
• Last updated: 2026-03-16
• Results posted: 2026-03-16

Locations

1 site across 1 country: United States