NCT05290688

Cellular microRNA Signatures in Multiple Sclerosis

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Institut Pasteur · Industry
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

A limited number of studies on microRNA expression variation in immune cells have been reported in relapsing-remitting multiple sclerosis (RRMS). These studies have been performed mostly on a small scale and on whole blood mononuclear cells (PBMC). In a number of cases, RRMS progresses to a severe secondary neurodegenerative form. In this context, it is important to look for biomarkers that could indicate the pathogenic activity of certain immune cell subpopulations.

Detailed description

SEP-MIR is a prospective, single-center, descriptive study. Participants will be recruited among adult patients with RRMS coming for a follow-up consultation in the Neurology Department, Nervous System Diseases Pole, at the hôpital Pitié - Salpêtrière (Paris). As this is a descriptive study, the recruitment of 20 participants (10 patients with relapsing-remitting MS and 10 patients with relapsing-remitting MS) should meet the objectives of this study. A 50 ml blood sample will be obtained from each participant and several clinical data regarding their pathology will be collected.

Conditions

• Multiple Sclerosis, Relapsing-Remitting

Interventions

Type	Name	Description
GENETIC	50 ml blodd sampling	50 ml blood sampling for genetic analysis (expression profiles of microRNAs)

Timeline

• Start date: 2022-09-15
• Primary completion: 2024-09-15
• Completion: 2024-09-15
• First posted: 2022-03-22
• Last updated: 2022-08-17

Locations

1 site across 1 country: France