NCT05290324

Propofol or Midazolam for Sedation and Early Extubation Following Coronary Artery Bypass Graft Surgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Chaudhry Pervaiz Elahi Institute of Cardiology · Other Government
• Sex: All
• Age: 20 Years – 20 Years
• Healthy volunteers: Not accepted

Summary

Propofol and midazolam are used frequently as sedating agents among patients who undergo coronary artery bypass graft surgery but no study in Pakistan has been done to compare their effectiveness aiming early extubation.

Detailed description

Propofol is an intra lipid and alkali phenol chemically it is unrelated to sedative agents or anaesthetic. Midazolam is a banzodiazepen. Most of its properties are similar to diazepam. It is a common practice to use sedatives to provide comfort and decrease "ventilator-asynchrony" in critically ill patients that may require prolonged invasive mechanical ventilation. The other reason to employ sedatives is to reduce the anxiety associated with the inaviseve procedures routinely conducted in the ICU.

Conditions

• Coronary Artery Disease

Interventions

Type	Name	Description
DRUG	Midazolam	Midazolam infusion will be given after the surgery as 0.25 mg/kg/min.

Timeline

• Start date: 2019-02-01
• Primary completion: 2020-02-01
• Completion: 2020-02-01
• First posted: 2022-03-22
• Last updated: 2022-03-22

Locations

1 site across 1 country: Pakistan