NCT05289440

Esketamine Administration on Recovery Quality After Radical Mastectomy

The Effect of Esketamine on the Quality of Recovery After Modified Radical Mastectomy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 105 (actual)
• Sponsor: Anqing Municipal Hospital · Academic / Other
• Sex: Female
• Age: 30 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Some studies have reported that intravenous esketamine reduce postoperative pain intensity. The investigators investigated whether esketamine could improve the the quality of recovery after modified radical mastectomy.

Detailed description

A total of 111 patients were randomly allocated into 3 groups. Patients in group LE received a bolus infusion of esketamine (0.5 mg/kg) before cutting the skin, and then esketamine was infused at a rate of 2 µg/kg/min until before suture the skin. Patients in group HE received a bolus infusion of esketamine (0.5 mg/kg) before cutting the skin, and then esketamine was infused at a rate of 4 µg/kg/min until before suture the skin. Patients in group CON received a bolus infusion of the same volume saline before cutting the skin, and then the same volume saline was infused until before suture the skin.

Conditions

• Esketamine and the Quality of Recovery

Interventions

Type	Name	Description
DRUG	Low-dose esketamine infusion	Patients received a bolus infusion of esketamine (0.5 mg/kg) before cutting the skin, and then esketamine was infused at a rate of 2 µg/kg/min until before suture the skin.
DRUG	High-dose esketamine infusion	Patients received a bolus infusion of esketamine (0.5 mg/kg) before cutting the skin, and then esketamine was infused at a rate of 4 µg/kg/min until before suture the skin.
DRUG	Saline infusion	Patients received a bolus infusion of the same volume saline before cutting the skin, and then the same volume saline was infused until before suture the skin.

Timeline

• Start date: 2022-03-15
• Primary completion: 2022-09-15
• Completion: 2022-09-20
• First posted: 2022-03-21
• Last updated: 2022-11-09

Locations

1 site across 1 country: China