NCT05289336

DAHANCA 27 Transoral Laser Microsurgery for T1a Glottic Cancer

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Danish Head and Neck Cancer Group · Network
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

To evaluate whether Transoral Laser Microsurgery (TLM) is non-inferior compared to Accelerated Radiotherapy (accRT) in the treatment of T1aN0M0 glottic SCC

Detailed description

Since 2003 the Danish national standard treatment for T1aN0M0 glottic SCC has been accelerated RT (66Gy. 2 GY/fraction, 6 fractions/week). In 2012 cordectomy type I-III using TLM was introduced as an experimental treatment. The DAHANCA 27 trial is a comparative non-inferiority phase II study comparing two timely separated national patient cohorts. Patients treated with radical TLM from September 2012 to April 2016 were included in the TLM cohort, and patients treated with accelerated RT from January 2003 to august 2012 were included in the RT cohort

Conditions

• Head and Neck Squamous Cell Carcinoma
• Glottic T1

Interventions

Type	Name	Description
PROCEDURE	Transoral Laser Microsurgery

Timeline

• Start date: 2012-09-01
• Primary completion: 2016-04-30
• Completion: 2022-05-01
• First posted: 2022-03-21
• Last updated: 2022-03-21

Locations

5 sites across 1 country: Denmark