NCT05287906

A Trial to Assess Steviol Glycosides on Acute Appetite Hormone Release

The Effects of Steviol Glycosides on Acute Appetite Hormone Release in Men and Women with Normal Weight, Overweight and Type 2 Diabetes

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 69 (actual)
• Sponsor: Midwest Center for Metabolic and Cardiovascular Research · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The objectives of this trial are to assess the effects of steviol glycoside alone or in combination with a glycemic carbohydrate on blood glucose and endocrine and gut hormone secretion vs. water and glucose in individuals with normal weight, overweight and type 2 diabetes mellitus (T2DM).

Conditions

• Overweight and Obesity
• Type 2 Diabetes Mellitus

Interventions

Type	Name	Description
OTHER	Water	Each subject will receive one control and three treatments in the crossover design. The control contains water only.
OTHER	Glucose	Each subject will receive one control and three treatments in the crossover design. The glucose contains water and glucose.
OTHER	Steviol Glycosides	Each subject will receive one control and three treatments in the crossover design. The Steviol Glycoside beverage contains water and steviol glycosides.
OTHER	Steviol Glycosides plus glucose	Each subject will receive one control and three treatments in the crossover design. The Steviol Glycoside plus glucose beverage contains water, glucose, and steviol glycosides.
OTHER	Rebaudioside A	A leaf-based, extracted stevia product to compare to the Eversweet in the normal weight group only. The Rebaudioside A contains water and rebaudioside A.

Timeline

• Start date: 2022-04-15
• Primary completion: 2024-06-05
• Completion: 2024-06-05
• First posted: 2022-03-18
• Last updated: 2024-09-19

Locations

3 sites across 1 country: United States