NCT05284656

Effect of Folic Acid and/or Pentoxifylline on Patients With Chronic Kidney Disease

The Potential Nephro-protective Effect of Folic Acid and/or Pentoxifylline on Patients With Chronic Kidney Disease

• Status: Active Not Recruiting
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Al-Azhar University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to evaluate the effect of administration of folic acid and /or pentoxifylline on patients with chronic kidney disease (CKD).

Detailed description

Chronic kidney disease (CKD) is a worldwide public health problem, with adverse outcomes of kidney failure, cardiovascular disease (CVD), and premature death. Chronic kidney disease (CKD) affects between 8% and 16% of the population worldwide.Defined by a glomerular filtration rate (GFR) of less than 60 mL/min/1.73 m2, albuminuria of at least 30 mg per 24 hours, or markers of kidney damage (eg, hematuria or structural abnormalities such as polycystic or dysplastic kidneys) persisting for more than 3 months.That nutrient loss because of diet restriction and chronic inflammation contributed by CKD itself may stimulate progression in advanced chronic kidney disease. Folic acid was then selected as a nutrient intervention. In the mean time, pentoxifylline was well studied in this field for its anti-inflammatory effects.Pentoxifylline (PTF) appears to improve circulation through its ability to alter erythrocyte deformability and enhances capillary microcirculation. This hemorheological property and the potential capacity in decreasing intraglomerular pressure has led to recent interest in PTF as a therapeutic agent in patients with kidney disease. In addition to these properties, PTF has an effect on inflammation, oxidative stress and endothelial function.

Conditions

• Chronic Kidney Diseases

Interventions

Type	Name	Description
DRUG	combination of Pentoxifylline 400 MG and Folic Acid	drugs used to delay progression of chronic kidney disease
DRUG	folic acid	drugs used to delay progression of chronic kidney disease
DRUG	Pentoxifylline 400 MG	drugs used to delay progression of chronic kidney disease

Timeline

• Start date: 2022-01-08
• Primary completion: 2026-06-12
• Completion: 2026-12-19
• First posted: 2022-03-17
• Last updated: 2025-06-11
• Results posted: 2025-06-11

Locations

1 site across 1 country: Egypt