NCT05282251

Intrapleural Nebulization of Bupivacain to Reduce Postoperative Pain

Pain Managment After VATS to Reduce Postoperative Pain and Improve Pulmonary Function

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Assiut University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Thoracic surgery is now common and as other surgeries evolution of minimally invasive techniques is employed. Video-assisted thoracic surgery (VATS) produces little scar but may produce severe pain that may affect the pulmonary function. Many procedure was developed like intercostal nerve block which require injections at multiple levels, Insertion of local anaesthetic (LA) in the surgical drain but that was dangerous due to the large amount of LA and not sufficient to completely eliminate pain. Bupvicaine nebulization, through surgical port which won't make any other wound, thought to be sufficient because Nebulization will enable us better distribution and less amounts of LA. Bupvicaine is local anaesthetic amide group that works by blocking sodium channels thus preventing progression of action potential.

Conditions

• Lung Diseases

Interventions

Type	Name	Description
DRUG	Intrapleural bupivacine nebulization	Intrapleural nebulization of bupivacine (10 ml of bupivacaine 0.5%) + Intravenous normal saline as a placebo
DRUG	Intravenous paracetamol and ketorolac	Intravenous analgesia: paracetamol (one gram) and Ketorolac (30 mg) + Intrapleural normal saline (10 ml) as a placebo

Timeline

• Start date: 2024-05-17
• Primary completion: 2024-07-15
• Completion: 2024-07-15
• First posted: 2022-03-16
• Last updated: 2024-05-20

Locations

1 site across 1 country: Egypt