NCT05280561

Stress-induced Sleep Deficits and a Complementary Therapy

Stress-, Anxiety-, and Cellphone Use-induced Sleep Deficits and Psychological Conditions During the Pandemic and a Potential Complementary Therapy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 288 (actual)
• Sponsor: University of Southern California · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The COVID-19 pandemic and social isolation order induced stress/anxiety as well as cellphone dependence. As a result, sleep disruption and mental distress became major health concerns. Gamma-aminobutyric acid type-A receptor (GABAAR) is one of the key players in modulating sleep. Dihydromyricetin (DHM), an herbal compound, plays a role in GABAAR modulation and mitigating anxiety. The investigators' partner in China obtained 288 participants who completed the online survey to gain insight into how stress/anxiety and time spent on cellphones affected sleep and mood. The participants were then enrolled in a randomized placebo-controlled double-blind study to assess the effects of DHM on sleep and improvement on stress/anxiety and cellphone using time.

Conditions

• Insomnia Due to Anxiety and Fear

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	DHM	DHM is a positive modulator of GABA. We hypothesize the DHM could reduce stress/anxiety induced insomnia during the pandemic
DIETARY_SUPPLEMENT	Placebo	Excipients including extracts of celery, strawberry, oranges, rose, and beet blended in powder form of 1 g

Timeline

• Start date: 2021-07-25
• Primary completion: 2022-10-31
• Completion: 2022-11-03
• First posted: 2022-03-15
• Last updated: 2023-01-05

Locations

1 site across 1 country: China