NCT05279183

Assessment of Reward Responses to Erythritol Using Flavor Preference Learning

Assessment of Reward Responses to Erythritol Using Flavor Preference Learning and Its Effects on Gastrointestinal Hormones, Glycemic Control, Appetite-related Sensations and Emotional State

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: University Hospital, Basel, Switzerland · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The aim of this project is to investigate the reward responses to oral erythritol compared to sucrose and sucralose using flavor preference learning in healthy participants. In addition, the release of GI hormones, glycemic control, appetite-related sensations, and emotional state in response to erythritol will be investigated.

Detailed description

This trial is a randomized, double-blind, cross-over study; the project set-up will be single-centre, national. The study is composed of six visits: one screening visit, one pre-test visit, three conditioning visits, and one post-test visit. The screening and pre-test will last about two hours, the conditioning days and the post-test day about 4 hours each. During the screening participants take part in a 6-n-propylthiouracil (PROP) sensitivity test to exclude potential supertasters. Moreover, the participants will rate explicit liking and explicit wanting of 10 non-caloric flavored and colored beverages in a randomized order (flavor preference learning). The pre-test visit consists of two parts. First, a chemosensory sweetness matching will be performed, during which we will establish dose-response relationships for perceived sweetness of sucrose, erythritol, and sucralose using equisweet watery solutions across a range of concentrations. Second, the participants will perform a triangle test to ensure that they cannot distinguish the matched erythritol and sucralose solutions from a 10% sucrose solution. During the 3 conditioning visits, participants will be presented with three conditioning trials (at t = 0, 45, and 90min), each consisting of drinking 100mL of the flavored drink (CS) paired with one of the sweet substances (US = erythritol, sucrose, or sucralose). In post-test visit, preference for each of the 3 flavored CS drinks will be assessed and a computerized forced choice task will be completed by the participants.

Conditions

• Reward Responses
• Gastrointestinal Hormones
• Glycemic Control
• Appetite
• Satiation
• Emotional State

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Erythritol	Subject specific dose of erythritol dissolved in 300 mL tap water.
DIETARY_SUPPLEMENT	Sucrose	30 g sucrose dissolved in 300 mL tap water.
DIETARY_SUPPLEMENT	Sucralose	Subject specific dose of sucralose dissolved in 300 mL tap water.

Timeline

• Start date: 2022-03-17
• Primary completion: 2022-09-16
• Completion: 2022-09-16
• First posted: 2022-03-15
• Last updated: 2022-10-12

Locations

1 site across 1 country: Switzerland