NCT05277779

EARLY Assessment of MYOcardial Tissue Characteristics in OBESITY (EARLY-MYO-OBESITY)

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 120 (actual)
• Sponsor: RenJi Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

EARLY-MYO-OBESITY-CMR is a prospective, three-center, cardiac imaging study to investigate cardiac morphology, function, and tissue phenotypes in a cohort of non-diabetic obese adults, and compare with metabolically healthy non-obese controls.

Detailed description

1. Transthoracic echocardiography was performed to analyze the LV morphology and function. 2. CMR was performed within 24 hours of the echocardiographic examination to assess the cardiac morphology , cardiac function, and myocardial tissue characteristics. Standard cine images were acquired to quantify LV function and volume. T1 mapping-derived ECV values were used to detect subtle diffuse fibrosis , and late gadolinium-enhanced (LGE) imaging was used to identify focal fibrosis. Native T2 values were obtained to quantify myocardial edema . Global longitudinal peak systolic strain (GLS) and e' SR were assessed by tissue tracking analysis to detect subclinical systolic and diastolic dysfunction.

Conditions

• Obese

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	cardiac magnetic resonance(CMR)	CMR was performed to assess myocardial tissue characteristics in the study population

Timeline

• Start date: 2019-01-01
• Primary completion: 2022-12-30
• Completion: 2022-12-30
• First posted: 2022-03-14
• Last updated: 2023-06-01

Locations

1 site across 1 country: China