NCT05277090

Bowel Preparation May Lead to a Higher Feasibility of Intestinal Infection

Bowel Preparation for Colonoscopy May Lead to a Higher Feasibility of Intestinal Infection: a Clinical and Basic Research

• Status: Unknown
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Yanqing Li · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

An adequate bowel preparation is essential for a high quality of colonscopy. Nowdays, polyethyleneglyco is considered the most safe drug for bowel preparation, and is widely used around the world. However, previous study illustrated that bowel preparation by polyethyleneglyco could lead to qualitative changes in the intestinal microbiota both in mice and human. This study is aimed to investigate wether the changes in the intestinal microbiota could lead to a higher rate of intestinal infection.

Conditions

• Healthy

Interventions

Type	Name	Description
DRUG	2L of polyethyleneglycol	2L of polyethyleneglycol
DIETARY_SUPPLEMENT	inulin	15g inulin per day
COMBINATION_PRODUCT	probiotic combination product	participants take 2L of polyethyleneglycol, subsequently take 15g probiotics combination product (including Bifidobacterium lactis, Lactobacillus plantarum, inlulin, Vitamin C) per day. The probiotic combination product, named "Mei Ri Yi Jun" was produced by Wedge Pharmaceuticals.

Timeline

• Start date: 2022-03-15
• Primary completion: 2022-03-15
• Completion: 2022-03-15
• First posted: 2022-03-14
• Last updated: 2022-03-14