NCT05277025

Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 150 (estimated)
• Sponsor: University of Florida · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Fibromyalgia (FM) is a chronic musculoskeletal pain disorder that afflicts up to 4% of the general population. The evaluation of pain mechanisms in FM has shown predominant central abnormalities and therefore has been designated as nociplastic pain syndrome. Rheumatoid arthritis (RA) is characterized by polyarthritis and pain from inflamed tissues, consistent with nociceptive pain. FM and RA patients may utilize overlapping pain mechanisms resulting in nociceptive and nociplastic pain.

Conditions

• Fibromyalgia
• Rheumatoid Arthritis

Timeline

• Start date: 2022-03-22
• Primary completion: 2026-02-28
• Completion: 2026-02-28
• First posted: 2022-03-14
• Last updated: 2025-06-24

Locations

1 site across 1 country: United States