NCT05272020

Outcome, Recuperation and Hemodynamics in Aortic Stenosis

PRognosis of Outcome and Recuperation of Cardiac Hemodynamic Function After Aortic Valve REplacement in Aortic Valve Stenosis

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (estimated)
• Sponsor: Jessa Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Indication for aortic valve replacement (AVR) in aortic stenosis (AS) is currently based on the classical triad of clinical AS symptoms, estimation of AS severity, and cardiac repercussion at rest. However, presence of symptoms in elderly is often subjective and underreported, and cardiac function analysis at rest underestimates the true impact of the chronic afterload increase. This complicates the diagnosis and hampers timely aortic valve replacement therapy with an impact on prognosis and cardiac function recovery. Exercise imaging in AS may reveal underlying cardiac repercussion and symptoms at an earlier stage and therefore impact prognosis and cardiac function recovery after AVR. Therefore the principal objective of this study is to reveal the factors that determine clinical outcome and hemodynamic function recovery after AVR in AS.

Conditions

• Aortic Valve Stenosis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	CPET, 6MWT, QOL assessment	Preoperative and postoperative (6 months + 18 months) assessment

Timeline

• Start date: 2021-03-22
• Primary completion: 2023-09-30
• Completion: 2024-03-31
• First posted: 2022-03-09
• Last updated: 2022-03-09

Locations

1 site across 1 country: Belgium