NCT05269537

Changes in Cardiac Output During Cesarean Delivery Under Spinal Anesthesia

Changes in Cardiac Output During Cesarean Delivery Under Spinal Anesthesia. A Prospective Observational Study Using Transthoracic Echocardiography

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (actual)
• Sponsor: Mansoura University · Academic / Other
• Sex: Female
• Age: 19 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

Cardiac output will be measured in healthy parturients undergoing cesarean delivery under spinal anesthesia

Detailed description

ASA-II women undergoing cesarean delivery under spinal anesthesia will be included. Cardiac output will be measured using transthoracic echocardiography at 4 time points: Baseline, after 10 minutes of intrathecal injection, after delivery, and after 1 hour of intrathecal injection. Spinal anesthesia will be administered with 2.5 ml bupivacaine 0.5% and fentanyl 15 μg.

Conditions

• Anesthesia, Spinal
• Cesarean Section
• Echocardiography
• Cardiac Output

Interventions

Type	Name	Description
RADIATION	Transthoracic Echocardiography	Measurement of cardiac output in supine position with left lateral tilt at baseline, at 10 minutes after intrathecal injection, immediately after delivery, and at 1 hour after intrathecal injection
PROCEDURE	Spinal Anesthesia	Performed at the L3-L4 or L4-L5 interspace using 25-gauge spinal needle
DRUG	Intrathecal Bupivacaine	Bupivacaine 12.5 mg (2.5 mL 0.5%) will be administered in the subarachnoid space
DRUG	Intrathecal Fentanyl	Fentanyl 15 μg will be administered in the subarachnoid space
DRUG	Crystalloid Coload 1000 mL	Ringer acetate 1000 mL will be administered over 10 minutes starting immediately after intrathecal injection
PROCEDURE	Cesarean Delivery	Lower segment cesarean section using the Pfannenstiel incision and uterine exteriorization
DRUG	Intravenous Ephedrine	Intravenous ephedrine 3, 5, and 10 mg will be administered when Systolic blood pressure decreases below 90%, 80%, and 70% of baseline, respectively.
DRUG	Oxytocin	Intravenous oxytocin 10 U in 500 mL Ringer acetate will be administered over 30 minutes starting immediately after delivery of the fetus

Timeline

• Start date: 2022-03-12
• Primary completion: 2022-07-02
• Completion: 2022-07-02
• First posted: 2022-03-08
• Last updated: 2022-11-29

Locations

1 site across 1 country: Egypt