NCT05269069

Impact of Rheumatoid Arthritis on Body Composition, Bone Marrow Adiposity and Bone Mineral Density: a Case-control Study

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 52 (actual)
• Sponsor: University Hospital, Lille · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

During rheumatoid arthritis (RA) (in comparison with control subjects), body composition is altered with a loss of lean body mass, bone mass and an accumulation of fat mass. Determination of total body fat and particularly its abdominal distribution (visceral adiposity) is important because of the cardiovascular (excess cardiovascular risk), metabolic (insulin resistance, diabetes and dyslipidemia) and bone (increased fracture risk) risks associated with this endocrine organ. Moreover, we do not have data concerning medullary adiposity in RA. This pilot case-control study will be compare body composition, bone marrow adiposity and bone mineral density in patients with RA versus healthy volunteers.

Conditions

• Rheumatoid Arthritis

Interventions

Type	Name	Description
OTHER	Assessment of body composition, bone mineral density and bone marrow adiposity.	DXA for body composition and bone mineral density, MRI for bone marrow adiposity and blood tests (leptine, CTX, P1NP)

Timeline

• Start date: 2022-08-17
• Primary completion: 2024-04-02
• Completion: 2024-04-02
• First posted: 2022-03-07
• Last updated: 2024-05-16

Locations

1 site across 1 country: France