NCT05268133

Aronia and Cognitive Fitness

Aronia and Cognitive Fitness: Focus on Brain Insulin-Sensitivity and Vascular Function

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: All
• Age: 55 Years – 75 Years
• Healthy volunteers: Accepted

Summary

Previously, beneficial effects of Aronia Melanocarpa extract (AME) supplementation on cognitive performance has been observed in healthy middle-aged adults. However, underlying mechanisms have not yet been addressed. In addition, effects of AME are unknown in subjects at increased risk of cognitive impairment. It is hypothesized that supplementation with AME enhances (regional) brain vascular function and brain insulin-sensitivity, thereby improving cognitive function of subjects at increased risk of cognitive impairment. The primary objectives are to investigate effects of AME intake on brain vascular function and insulin-sensitivity in cognitive-control brain areas, while we will also evaluate changes in cognitive function (secondary objective). The present study is a randomized, double-blind, placebo-controlled, cross-over trial consisting of two study groups and a pre- and post-test day in both study arms.

Conditions

• Brain Vascular Function
• Cognition

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Aronia	As described in experimental arm
DIETARY_SUPPLEMENT	Control	As described in placebo comparator arm

Timeline

• Start date: 2022-06-08
• Primary completion: 2023-08-25
• Completion: 2023-08-25
• First posted: 2022-03-07
• Last updated: 2025-09-24

Locations

1 site across 1 country: Netherlands