NCT05267678

Nutritional Deficiency and Recurrent Miscarriage

A Cohort Study Investigating Nutritional Deficiency Among Pregnant Women With History of Recurrent Miscarriage

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 499 (estimated)
• Sponsor: Westlake University · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

This prospective cohort study primarily aims to examine the association between blood niacin levels and recurrent miscarriage.

Detailed description

Recurrent miscarriage is affecting around 5% women at reproductive age. And the underlying causes remain undetermined in 50%-70% of cases. Although animal models and linkage analysis according to family studies have identified that niacin deficiency can lead to congenital malformations and recurrent miscarriage. Evidence based on population is lacking with regard to the effect of blood niacin levels on recurrent miscarriage. We intend to enroll 499 pregnant women confirmed by a positive blood human chorionic gonadotropin test and with history of unexplained recurrent miscarriage. By testing their blood niacin levels and following up to the end of first-trimester pregnancy, this study aims to examine the role of niacin levels in preventing miscarriages among women with history of recurrent miscarriage.

Conditions

• Recurrent Miscarriage

Interventions

Type	Name	Description
OTHER	No intervention	This is an observational study without any intervention

Timeline

• Start date: 2023-01-28
• Primary completion: 2024-04-01
• Completion: 2024-07-01
• First posted: 2022-03-04
• Last updated: 2023-06-01

Locations

1 site across 1 country: China