NCT05266872

Earlier Diagnosis and Better Treatment Mission Related to the Cohort Programme

Biomaterial Collection for Neurodegenerative Disease Research (ND Collection)

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 1,800 (estimated)
• Sponsor: Luxembourg Institute of Health · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The Luxembourg Parkinson's Study is an ongoing longitudinal nationwide monocentric observational study. It collects extensive clinical, molecular, genetic, and digital device-based longitudinal data, as well as foreseen post-mortem diagnostic validation (Hipp et al., 2018). The cohort consists of more than 1,600 participants from Luxembourg and the Greater Region, comprising patients with typical PD or atypical parkinsonism - irrespective of disease stage, age, cognitive status, comorbidities, or linguistic background - followed-up annually and age- and sex-matched healthy control subjects followed-up every 4 years. To provide a large, longitudinally followed, and deeply phenotyped set of patients and controls for clinical and fundamental research on PD, the investigators have implemented an open-source digital platform that has been partly harmonized with other international PD cohort studies. This effort is flanked by comprehensive biosampling efforts assuring high quality and sustained availability of body liquids and tissue biopsies (including blood, urine, stool, saliva, hair, skin biopsy and cerebrospinal fluid). All data and samples are stored, curated, and integrated into state-of-the-art data and biobank facilities.

Conditions

• Parkinson Disease

Interventions

Type	Name	Description
OTHER	Observational study with sample and data collection	Observational study with sample and data collection

Timeline

• Start date: 2014-12-19
• Primary completion: 2025-12-31
• Completion: 2025-12-31
• First posted: 2022-03-04
• Last updated: 2025-08-06

Locations

2 sites across 1 country: Luxembourg