NCT05266794

A Novel Role of Alpha Lipoic Acid in Comparison With Selenium in Mitochondrial Resuscitation and miRNA-126 Expression in Hemodialysis Patients

A Novel Role of Alpha Lipoic Acid in Comparison With Selenium in Mitochondrial Resuscitation and miRNA-126 Expression in Hemodialysis Patients Randomized, Prospective, Controlled Study

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 68 (actual)
• Sponsor: Ain Shams University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

An Open labeled, Paralled, Randomized, Prospective, study was conducted on 60 patients who were randomized into 3 groups, 22, 20 and 18 patients in Control, Selenium and, Thiotacid groups respectively. Serum levels of ROS, CoQ10, and miRNA-126 were assessed at base line and after three months for all patients.

Conditions

• Antioxidative Stress
• End Stage Renal Disease on Dialysis

Interventions

Type	Name	Description
DRUG	Alpha lipoic acid	20 patients who received Alpha Lipoic acid (ALA) (Thiotex fort®) 600mg once daily with their routine therapy just after the dialysis sessions for 3 months.
DRUG	Selenium	23 patients who received Selenium 200µg once daily with their routine therapy just a

Timeline

• Start date: 2019-01-22
• Primary completion: 2019-04-23
• Completion: 2019-04-30
• First posted: 2022-03-04
• Last updated: 2022-03-04

Locations

1 site across 1 country: Egypt