NCT05266144

Atrial Fibrillation Patients Treated With Catheter Ablation

A Prospective Cohort Study of Atrial Fibrillation Patients Treated With Catheter Ablation

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 300 (estimated)
• Sponsor: Peking Union Medical College Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This is a single-center prospective observational cohort study of atrial fibrillation patients treated with radiofrequency ablation.

Detailed description

The effect of radiofrequency therapy on the life quality and atrial function of atrial fibrillation patients will be assessed, through the multidimensional analysis of baseline clinical data, serological indicators of atrial fibrosis, echocardiography, cardiac magnetic resonance imaging, atrial potential mapping, life quality, and long-term ECG monitoring within 1 week after radiofrequency ablation. A predictive model for atrial fibrillation recurrence after ablation will be established. Based on the cross-sectional analysis of baseline data, the relationship between non-invasive assessment of atrial fibrosis (imaging and serology), atrial electrical activity, and atrial function will be analyzed as well, and atrial fibrillation patients with ventricular fibrosis will be selected for gene sequencing to explore the existence of underlying cardiomyopathy and provide data for further research.

Conditions

• Atrial Fibrillation
• Atrial Fibrillation Recurrent

Interventions

Type	Name	Description
PROCEDURE	radiofrequency ablation	Bilateral pulmonary vein isolation, a kind of radiofrequency ablation, is performed in atrial fibrillation patients for atrial arrhythmia therapy.

Timeline

• Start date: 2020-09-04
• Primary completion: 2025-10-01
• Completion: 2025-12-31
• First posted: 2022-03-04
• Last updated: 2025-06-05

Locations

1 site across 1 country: China