NCT05265871

ATP Level and Cough Sensitivity to ATP in Subjects With Refractory/Unexplained Chronic Cough

ATP Level in Induced Sputum and Cough Sensitivity to ATP in Subjects With Refractory/Unexplained Chronic Cough

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 131 (actual)
• Sponsor: Kefang Lai · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This is a cross-sectional study to investigate ATP level in induced sputum and cough sensitivity to ATP in subjects with refractory/unexplained chronic cough. 60 patients with refractory/unexplained chronic cough and 30 matched healthy controls were recruited. Demographic data, clinical characteristic, cough sacles and medical history records were collected. Cough chanllage(ATP and capsaicin) and ATP measurement in sputum were conducted.The difference of sputum ATP level between patients and control and the correlation between sputum ATP level and cough sensitivity to ATP were analyzed.

Conditions

• Refractory/Unexplained Chronic Cough

Timeline

• Start date: 2022-05-16
• Primary completion: 2024-01-24
• Completion: 2024-01-24
• First posted: 2022-03-04
• Last updated: 2025-05-11
• Results posted: 2025-05-11

Locations

1 site across 1 country: China