NCT05265455

Diet and Plant Sterols in the Control of Cholesterolemia (DESCO)

Randomized Clinical Trial, Controlled Against Placebo, Performed to Evaluate the Effect of a Phytosterol-based Product (2.5 g/Day), After 3 Weeks of Intake, on the Lipid Profile, Also in Relation to the Quality of the Diet, in Subjects With Moderate Hypercholesterolemia and Low / Moderate Global Cardiovascular Risk

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: University of Bologna · Academic / Other
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Accepted

Summary

DESCO is a randomized clinical trial, controlled against placebo, performed to evaluate the effect of a phytosterol-based product (2.5 g/day), after 3 weeks of intake, on the lipid profile, also in relation to the quality of the diet, in subjects with moderate hypercholesterolemia and low / moderate global cardiovascular risk.

Detailed description

This is a randomized, placebo-controlled, double-blind, monocentric cross over clinical study conducted in Italy. The objective of this study is to evaluate the fasting lipid profile of adults with moderate hypercholesterolemia and a low/very low cardiovascular risk, after 3 weeks of supplementation with 2.5 g/day of plant sterols, vs placebo, and to assess the relationship between the effects of the supplementation and the diet.

Conditions

• Hypercholesterolemia

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Plant sterols 2.5 g/day	Daily consumption of one stick (2.5 g of plant sterols) during lunch or dinner for 3 weeks
DIETARY_SUPPLEMENT	Placebo	Daily consumption of one stick (the same matrix without plant sterols) during lunch or dinner for 3 weeks

Timeline

• Start date: 2021-10-01
• Primary completion: 2022-06-08
• Completion: 2022-06-08
• First posted: 2022-03-03
• Last updated: 2024-01-31

Locations

1 site across 1 country: Italy