NCT05261256

Cardiac Impairments Following Pediatric Cardiotoxic Anti-cancer Treatment

Early Detection of Cardiac Impairments Following Cardiotoxic Anti-cancer Treatment During Childhood and Adolescence - A Feasibility Study

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 80 (estimated)
• Sponsor: Technical University of Munich · Academic / Other
• Sex: All
• Age: 10 Years – 25 Years
• Healthy volunteers: Accepted

Summary

This study aims at investigating the feasibility of recruitment and application of a method regarding early detection of subclinical changes in cardiac health after completion of acute cancer treatment during childhood and adolescence.

Detailed description

Cardiovascular late effects following treatment for pediatric cancer are problematic. Early detection of subclinical changes is hardly possible using conventional diagnostic methods, but seems to be feasible during physical strain (exercise stress echocardiography). This feasibility study examines as main objective the recruitment strategy and investigation method in 10-25-year olds in the first and fifth year after the end of acute anti-cancer therapy (n=40 participants with a history of childhood cancer and n=40 control subjects). The heart function is examined by means of exercise stress echocardiography and spiroergometry in comparison with healthy age- and gender-matched control subjects. Secondary aims are the evaluation of aditional echocardiography markers and levels of physical activity.

Conditions

• Cardiovascular Diseases
• Pediatric Cancer

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Exercise stress echocardiography	Study participants perform an exercise stress echocardiography on a semi-supine bicycle ergometer using using a continuous incremental bicycle protocol with a work rate increment every 3 minutes according to gender and weight.

Timeline

• Start date: 2022-02-01
• Primary completion: 2024-10-31
• Completion: 2024-12-31
• First posted: 2022-03-02
• Last updated: 2023-12-05

Locations

1 site across 1 country: Germany