NCT05255952

Epicardial Stimulation of the Cardiac Autonomic Nervous System

EpiCANS : Epicardial Stimulation of the Cardiac Autonomic Nervous System

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 4 (actual)
• Sponsor: Rennes University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The objective of the EpiCANS study is to evaluate the technique of stimulation of the cardiac autonomic nervous system (SNAC) directly at the epicardial level in humans during heart surgery. Proof of concept study

Detailed description

Isolated stimulation of the parasympathetic system induces a protective effect on long-term cardiac remodeling, but at the cost of inhibiting the sympathetic system. The role of the sympathetic system is to increase cardiac output in cases of acute heart failure. Electrical stimulation of the cardiac plexus directly at the level of the heart allows simultaneous stimulation of the sympathetic and parasympathetic systems, whose complementary and not automatically antagonistic role is now recognized. Thus, direct stimulation of the plexus would optimize cardiac function in the short and long term by instantly improving cardiac output and decreasing pulmonary resistance as described in dogs by Kobayashi et al. The objective of the EpiCANS study is to evaluate this technique in humans during cardiac surgery.

Conditions

• Cardiac Insufficiency

Interventions

Type	Name	Description
PROCEDURE	Electrical stimulation	Electrical stimulation of the cardiac plexus

Timeline

• Start date: 2022-08-16
• Primary completion: 2023-10-13
• Completion: 2023-11-13
• First posted: 2022-02-25
• Last updated: 2024-09-27

Locations

1 site across 1 country: France