NCT05255172

Exercise Intervention in Patients With Heart Failure With Preserved and Reduced Ejection Fraction

Physiological Mechanisms Affecting Exercise Capacity in Patients With Heart Failure - an Exercise Intervention Study Evaluated With Several Modalities

• Status: Enrolling By Invitation
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: Region Skane · Academic / Other
• Sex: All
• Age: 50 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

The objective of this study is to assess by what physiological mechanisms patients with heart failure benefit from exercise. Effects of an exercise intervention will be assessed for both central (heart and lungs) and peripheral (muscle fiber and mitochondria) factors.

Detailed description

A randomized, non-blinded prospective intervention trial. Patients randomized to exercise intervention will undergo supervised aerobic training on ergometer cycle for 12 weeks whilst control group receives standard care. Before and after the intervention, all participants will undergo cardiac magnetic resonance imaging (cardiac MR) examinations, Ventilation/Perfusion Single Photon Emission Computed Tomography (V/P SPECT), Cardiopulmonary exercise tests, muscle biopsies and blood sampling.

Conditions

• Heart Failure New York Heart Association (NYHA) Class II
• Heart Failure New York Heart Association (NYHA) Class III

Interventions

Type	Name	Description
OTHER	Supervised Exercise	12 weeks of supervised aerobic exercise individually adapted to exercise capacity according to a VO2 peak test

Timeline

• Start date: 2022-06-01
• Primary completion: 2027-08-31
• Completion: 2027-12-31
• First posted: 2022-02-24
• Last updated: 2025-06-29

Locations

1 site across 1 country: Sweden