NCT05254145

Joint Microbiome Study for the Knee

Insight of Joint Microbiome From Different Knee Conditions.

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Rothman Institute Orthopaedics · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Prosthetic joint infection (PJI) is a devastating complication following arthroplasty. An utmost effort has been done to clarify risk factors and microbiology of PJI. We now know the most frequent infecting microorganisms are members of the skin microbiome. These microorganisms are thought to get into the joint and infect the prosthesis during the peri-operative and/or post-operative period. Nevertheless, recent studies have suggested, bacteria may be present in the joint even before the first incision, suggesting the existence of a joint microbiome. Therefore, we aimed to determine the bacterial composition from different knee conditions.

Conditions

• Knee Osteoarthritis
• PJI

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Next Generation Sequencing	During the participants surgical procedure, a total of 3 ml of synovial fluid (joint fluid collected from the knee) will be collected per joint. Upon collection, the samples will be deidentified, stored on ice and shipped with a study ID number to MicroGenDx for Next Generation Sequencing.

Timeline

• Start date: 2022-02-20
• Primary completion: 2023-02-28
• Completion: 2023-02-28
• First posted: 2022-02-24
• Last updated: 2022-02-24

Locations

1 site across 1 country: United States