NCT05247515

Evaluation of Nexpowder Application to Prevent Delayed Bleeding After Colorectal Endoscopic Mucosal Resection

Evaluation of Nexpowder Application to Prevent Delayed Bleeding After Large Colorectal Endoscopic Mucosal Resection

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 304 (estimated)
• Sponsor: Gabriel RAHMI · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

Delayed bleeding is the most frequent (5 to 15%) and challenging complication after large colorectal polypectomy. Different preventive treatments, such as the prophylactic use of clips, have been tried to prevent the occurrence of delayed bleeding, but to date, no treatment has clearly shown its effectiveness. In addition, preventive hemostasis with clips is difficult and costly. A newly developed endoscopic hemostatic powder generating gelation effect (Nexpowder) may be an effective alternative to prevent post polypectomy bleeding in patients treated by endoscopic mucosal resection (EMR) for large superficial colorectal lesions.

Conditions

• Colorectal Cancer

Interventions

Type	Name	Description
DEVICE	Endoscopic mucosal resection with nexpowder	At the end of the EMR procedure, the patient will be randomized. In the treated group, Nexpowder will be sprayed thanks to a catheter inserted through the operating channel of the endoscope.

Timeline

• Start date: 2022-07-01
• Primary completion: 2022-08-01
• Completion: 2024-08-01
• First posted: 2022-02-21
• Last updated: 2022-02-21

Locations

1 site across 1 country: France