NCT05246631

Haloperidol and Dexamethasone Towards Postoperative Nausea and Pain in Adult After Laparoscopy

Haloperidol Compared to Dexamethasone in Lowering Postoperative Nausea and Vomiting and Pain in Adult After Laparoscopy

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Indonesia University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This study aim to find out the effectiveness of 1 mg intravenous haloperidol compared to 5 mg intravenous dexamethasone to prevent the occurrence of nausea and vomiting also as pain control in adult patients after laparoscopic surgery.

Detailed description

Eighty subjects (n=40 for each group) scheduled for laparoscopic-assisted surgery were enrolled in a randomized double-blind clinical trial. One milligram intravenous haloperidol was given one hour before the end of surgery, while 5 mg intravenous dexamethasone was given right after induction. The occurrence of Postoperative Nausea and Vomiting (PONV) and visual analog scale (VAS) pain score were recorded.

Conditions

• Laparoscopy
• Postoperative Nausea and Vomiting

Interventions

Type	Name	Description
DRUG	Dexamethasone injection	Group A consisted of patients given 5 mg intravenous dexamethasone after induction.
DRUG	Haloperidol Injection	Group B consisted of patients given 1 mg intravenous haloperidol one hour before the surgery ended

Timeline

• Start date: 2020-01-01
• Primary completion: 2020-03-30
• Completion: 2020-07-30
• First posted: 2022-02-18
• Last updated: 2022-02-18

Locations

1 site across 1 country: Indonesia

Regulatory

• FDA-regulated drug study