NCT05246371

Propofol/Dexmedetomidine Versus Desflurane Effects on Post Hepatectomy Hepatocellular Injury

• Status: Unknown
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Ain Shams University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

This study will compare the effects of propofol/dexmedetomidine versus desflurane for maintenance of general anesthesia on hepatocellular injury in patients undergoing partial hepatectomy.

Detailed description

Postoperative impairment of liver function is common after hepatectomy. It may be caused by surgical trauma, loss of hepatic mass, stress response, hepatic oxygen deprivation, infection and drug toxicity. Anesthetic agents used in general anesthesia for liver surgery have a big effect on hepatic blood flow, oxygen delivery and liver function This study will compare the effects of propofol/dexmedetomidine versus desflurane for maintenance of general anesthesia on hepatocellular injury in patients undergoing partial hepatectomy.

Conditions

• Hepatectomy

Interventions

Type	Name	Description
DRUG	Propofol, dexmedetomidine	Patients will receive maintenance of general anesthesia by TIVA using combination of propofol and dexmedetomidine.
DRUG	Desflurane	Patients will receive maintenance of general anesthesia by desflurane.

Timeline

• Start date: 2021-06-01
• Primary completion: 2021-11-01
• Completion: 2023-11-01
• First posted: 2022-02-18
• Last updated: 2023-01-18

Locations

1 site across 1 country: Egypt