Trials / Recruiting
RecruitingNCT05246345
Venetoclax Resistance Landscape in Chronic Lymphocytic Leukemia
- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 50 (estimated)
- Sponsor
- University Hospital, Clermont-Ferrand · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to collect medical informations and samples from refractory and/or relapsed chronic lymphocytic leukemia during or after venetoclax treatment, in order to evaluate the frequency of resistance mechanisms.
Detailed description
The purpose of this study is to collect medical informations and samples (blood, bone marrow and/or lymph node) from refractory and/or relapsed chronic lymphocytic leukemia during or after venetoclax treatment, in order to evaluate the frequency of resistance mechanisms (BCL2 mutations, over-expression of other members of the BCL2 protein family and energy metabolism changes).
Conditions
- Chronic Lymphocytic Leukemia
- CLL
- Progressive Chronic Lymphocytic Leukemia
- Refractory Chronic Lymphocytic Leukemia
- Relapsed Chronic Lymphocytic Leukemia
Timeline
- Start date
- 2022-03-07
- Primary completion
- 2027-03-01
- Completion
- 2027-03-01
- First posted
- 2022-02-18
- Last updated
- 2024-01-09
Locations
14 sites across 1 country: France
Source: ClinicalTrials.gov record NCT05246345. Inclusion in this directory is not an endorsement.