NCT05240183

Viral Dynamics of Omicron in Children

Viral Dynamics of the SARS-CoV-2 Omicron Variant in Paediatric Patients

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 107 (actual)
• Sponsor: The Hospital for Sick Children · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

SARS-CoV-2 transmission is dependent on multiple factors, which may be related to either host-virus interaction or the environment. While there have been several studies evaluation viral dynamics and transmission risk in adults, there is limited pediatric data available. The objective of this study is to characterize the period of communicability for children less than 19 years of age with SARS-CoV-2 infection with the Omicron variant.

Detailed description

The goal of our study is to assess the viral dynamics of SARS-CoV-2 infection in children \< 19 years with acute infection to inform public health practice. Specific Aims: 1. Describe the kinetics of SARS-CoV-2 viral load in children with acute SARS-CoV-2 infection 2. Assess the impact of various host factors on viral dynamics, including age (\<1 year, 1-4 years, 5-11 years, 12-18 years), symptoms, clinical severity (hospitalization vs. outpatient), comorbidities (immunocompromised vs. not immunocompromised), vaccination (none, 1 dose, 2 doses) 3. Estimate the time point at which children are less likely to be infectious 4. Assess the sensitivity of self-collected rapid antigen testing (RAT) in children, compared to PCR (e.g. assess RAT test performance in children)

Conditions

• SARS-CoV2 Infection, COVID-19

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Daily SARS-CoV-2 PCR Testing for 10 days	Each participant will undergo daily SARS-CoV-2 PCR testing to assess viral dynamics

Timeline

• Start date: 2022-02-04
• Primary completion: 2022-03-31
• Completion: 2022-08-31
• First posted: 2022-02-15
• Last updated: 2022-11-28

Locations

1 site across 1 country: Canada