NCT05234697

Effect of Daytime Variation on Postoperative Hyperalgesia Induced by Opioids

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (actual)
• Sponsor: The Second Affiliated Hospital of Chongqing Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

To explore the effect of daytime variation on postoperative hyperalgesia induced by opioids. Patients receiving endoscopy surgery under general anesthesia during 08:00-12:00(morning group, n=30) and 14:00-18:00(afternoon group, n=30) using remifentanil for anesthesia maintenance were respectively included. Postoperative hyperalgesia at PACU and 24 hours after surgery were assessed through mechanical pain measurement. Comparative analysis of postoperative hyperalgesia levels, pain and analgesic requirements between morning group and afternoon group were performed.

Conditions

• Postoperative Hyperalgesia

Interventions

Type	Name	Description
DRUG	Remifentanil	Remifentanil was used for maintenance of anesthesia.

Timeline

• Start date: 2022-01-12
• Primary completion: 2022-05-20
• Completion: 2022-05-20
• First posted: 2022-02-10
• Last updated: 2022-12-28

Locations

1 site across 1 country: China

Regulatory

• FDA-regulated drug study