NCT05233917

Effects of Olive Oil and MLCT on Glycolipid Homeostasis in Patients With Metabolic Syndrome

The Precision Nutritional Management for MetS (PNMM)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 240 (actual)
• Sponsor: Zhejiang University · Academic / Other
• Sex: All
• Age: 40 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The type of cooking oil used is a crucial factor influencing dietary quality. The purpose of this study is to investigate the effects of olive oil and MLCT oil intervention on glucose and lipid homeostasis in patients with MetS.

Detailed description

We conducted a 6-month RCT to evaluate the effects of olive oil and MLCT as cooking oils on glucose and lipid homeostasis in patients with MetS; investigate the changes in lipoprotein subfractions and metabolites using NMR spectroscopy, alongside gut microbiota alterations, to elucidate potential mechanisms; and identify baseline variables associated with the anti-obesity effects of olive oil and MLCT.

Conditions

• Hyperlipidaemia
• Metabolic Syndrome

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Olive oil use	Olive oil, 25-30g/d by day for 6 month
DIETARY_SUPPLEMENT	MLCT oil use	MLCT oil, 25-30g/d by day for 6 month

Timeline

• Start date: 2023-06-09
• Primary completion: 2023-12-09
• Completion: 2023-12-22
• First posted: 2022-02-10
• Last updated: 2024-11-15

Locations

1 site across 1 country: China