NCT05233449

NoL Index Response to Stimulation in Anesthetized Children

Nociception Level Index (NoL) Variation After Standardized Stimulation Under General Anesthesia in Children

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: University Hospital, Lille · Academic / Other
• Sex: All
• Age: 5 Years – 12 Years
• Healthy volunteers: Not accepted

Summary

The Nociception Level (NoL) is an index obtained via a non-invasive monitor, that is currently used to assess nociception in anesthetized adults. The NoL index varies from 0 to 100. It increases in response to nociceptive stimuli. The objective of this study was to investigate if the NoL index also indicates the level of nociception in anesthetized children. In children anesthetized according to standard practice, before surgical incision, three 5-seconds stimulations will be performed with different intensities (10, 30 and 60 milliamps). The order of the stimulations intensities will be randomized. The hypothesis of study is that the intensity of stimulation will influence the magnitude of NoL-index increase in response to the stimulation.

Conditions

• Anesthesia

Interventions

Type	Name	Description
DEVICE	NoL monitor	NoL monitor : non invasive, adhesive digital device
PROCEDURE	Stimulation	Stimulation : 100 Hertz, 5 seconds, 10-30-60 milliamps, inner forearm

Timeline

• Start date: 2022-03-04
• Primary completion: 2022-05-17
• Completion: 2022-05-17
• First posted: 2022-02-10
• Last updated: 2025-12-26

Locations

2 sites across 1 country: France