NCT05231213

Effects of Neuromodulation and Cognitive Training for Suicide in Veterans (ENACTS)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 14 (actual)
• Sponsor: VA Office of Research and Development · Federal
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Impaired executive function, such as impaired decision making and impulsivity, has been identified as an important contributor to the transition from suicidal ideation to suicide attempt. To address the epidemic of Veteran suicide in the United States, this study tests the feasibility, acceptability, and preliminary effectiveness of a five day transcranial direct current stimulation (tDCS) augmented executive functioning training intervention. This intervention is delivered to high suicide risk inpatients. The ultimate goal is to reduce future suicide events (ideation, attempts, deaths) and improve quality of life (e.g. social relationships, health resource utilization).

Conditions

• Suicide
• Impulsivity

Interventions

Type	Name	Description
DEVICE	Active Transcranial Direct Current Stimulation (tDCS)	Cognitive training concurrent with 2 mAmps of anodal stimulation applied to the left frontal cortex for 20 minutes.
DEVICE	Sham Transcranial Direct Current Stimulation (tDCS)	Cognitive training concurrent with sham tDCS (30 secs ramp up/ramp down of current at beginning and end of session).

Timeline

• Start date: 2022-07-01
• Primary completion: 2025-03-31
• Completion: 2025-03-31
• First posted: 2022-02-09
• Last updated: 2025-05-07

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study