NCT05228223

Comparison of Sugammadex and Sugammadex-neostigmine Combination in the Antagonism of Moderate Neuromuscular Block

Comparison of Sugammadex and Sugammadex-neostigmine Combination in the Antagonism of Moderate Neuromuscular Block Induced by Rocuronium: A Prospective Randomized Cotrolled Study

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: Ankara City Hospital Bilkent · Academic / Other
• Sex: Female
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

In this prospective randomized controlled study the investigators compare the sugammadex-neostigmine combination and single dose sugammadex in terms of side effects and cost for the antagonism of moderate neuromuscular block induced by rocuronium.

Detailed description

Sugammadex is a novel drug used to reverse neuromuscular blockade. It shows its effect by binding with steroid neuromuscular agents at a ratio of 1:1. Compared to anticholinesterase and other neuromuscular reverse agents, sugammadex shows less cholinergic side effects and less residual muscle relaxation. Besides all these, sugammadex reverses neuromuscular blockade very quickly. In addition to these benefits, it has side effects such as hypersensitivity and this side effect can be seen more at high doses. In addition, sugammadex is more costly than other neuromuscular reverse agents. In this prospective randomized controlled study the investigators compare the sugammadex-neostigmine combination and single dose sugammadex in terms of side effects and cost for the antagonism of moderate neuromuscular block induced by rocuronium.

Conditions

• Residual Neuromuscular Block
• Neuromuscular Blockade Monitoring

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Neuromuscular monitoring	TOF monitoring
OTHER	reverse of NMB with sugammadex	Patients reversed with Sugammadex 2mg/kg after TOF count is 1-2.
OTHER	reverse of NMB with Sugammadex and neostigmin low dose	Patients reversed with Sugammadex 1mg/kg + Neostigmin 0.02 mg/kg
OTHER	reverse of NMB with Sugammadex and neostigmin high dose	patients reversed with sugammadex 1.5 mg/kg + Neostigmin 0.02 mg/kg

Timeline

• Start date: 2022-02-01
• Primary completion: 2022-05-01
• Completion: 2022-06-01
• First posted: 2022-02-08
• Last updated: 2022-02-08

Locations

1 site across 1 country: Turkey (Türkiye)