NCT05221346

Effect of Oleactiv® on LDL Oxidability

Effect of Oleactiv® on LDL Oxidability in Volunteers With Moderate Hypercholesterolemia - a Controlled, Randomized, Double-blind Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 26 (actual)
• Sponsor: Institut Pasteur de Lille · Academic / Other
• Sex: Male
• Age: 40 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Oleactiv® have previously demonstrated beneficial effects in an animal model of diet-induced atherosclerosis. After a 12-week supplementation, a substantial reduction of aortic fatty streak area has been observed. Also, Oleactiv®-supplemented hamsters displayed significant decrease of both non-HDL-cholesterol and triglycerides levels. Also, phenolic compounds from Oleactiv® demonstrated that increase of cholesterol efflux capacity (CEC) is one of the mechanisms that may explain preventive effect on atheroma development. These effects observed in animals will thus be investigated in human. The main hypothesis of the present study is that phenolic compounds from Oleactiv® may improve LDL oxidability in volunteers with moderate hypercholesterolemia after 3 weeks of consumption.

Conditions

• Hypercholesterolemia

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Plant food supplement	Food supplements are consumed during 3 weeks by hypercholesterolemic volunteers
DIETARY_SUPPLEMENT	Maltodextrin	Food supplements are consumed during 3 weeks by hypercholesterolemic volunteers

Timeline

• Start date: 2021-12-13
• Primary completion: 2022-10-11
• Completion: 2022-10-11
• First posted: 2022-02-03
• Last updated: 2022-12-07

Locations

1 site across 1 country: France