NCT05219006

Ketogenic Diet Effects on the Frequency of Non Epileptic Seizures

Ketogenic Diet Effects on the Frequency of Non Epileptic Seizures in Patients With Dissociative Neurological Symptom Disorder: a Pilot Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 17 (actual)
• Sponsor: El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez · Academic / Other
• Sex: All
• Age: 17 Years
• Healthy volunteers: Not accepted

Summary

The objective of this study is to determine the effects of the ketogenic diet on the frequency of non-epileptic seizures in patients with functional neurological symptoms disorder compared to a healthy diet.

Detailed description

This study consists of a open label randomized controlled clinical trial comprised of 20 patients with diagnosis of functional neurological symptom disorder with non epileptic seizures distributed in 2 arms of 10 patients each. Patients will be randomly assigned to one of the groups. Both groups will be receiving treatment as usual (SSRI and/or psychotherapy). One group will be assigned a ketogenic diet while the other will be assigned a healthy diet, both supervised by a team of nutritionists. Patients will be evaluated every 2 weeks until reaching 6 weeks.

Conditions

• Non Epileptic Seizures
• Functional Neurological Symptom Disorder
• Conversion Disorder
• Ketogenic Dieting

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	ketogenic dieting	Atkins modified diet: 1.2-1.5 g/kg/day of protein with a ratio 1:1 (fat: carbohydrate + protein)
DIETARY_SUPPLEMENT	healthy dieting	Normocaloric diet established by a nutritionist. 1.2-1.5 g/kg/day of protein with a maximum contribution of 50 % carbohydrates of the total calorie intake eliminating industrialized food.

Timeline

• Start date: 2021-07-15
• Primary completion: 2023-05-20
• Completion: 2023-07-02
• First posted: 2022-02-01
• Last updated: 2023-09-28

Locations

1 site across 1 country: Mexico