NCT05216822

Anti-Secretory Drug in Treatment of Acute Watery Diarrhea

Role of Anti-Secretory Drug in Treatment of Children With Acute Watery Diarrhea

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: Assiut University · Academic / Other
• Sex: All
• Age: 6 Months – 5 Years
• Healthy volunteers: Not accepted

Summary

In conclusion, racecadotril is an anti-secretory drug that exerts its antidiarrheal effect by inhibiting intestinal enkephalinase. It is effective in reducing the volume and frequency of stool output. racecadotril is well tolerated and safe by providing symptomatic relief and reducing the severity of diarrhea as an adjuvant therapy during the acute attack of gastroenteritis. It is recommended that the new generations of already discovered drugs for control of secretory diarrhea should be studied to discover the ones with fewer side effects to other systems in the body.

Detailed description

Background: Previous studies have shown that racecadotril is a safe and effective drug in treating children with acute diarrhea. Study Aim: to evaluate the effect of racecadotril as an adjunct to oral rehydration solution in the treatment of acute watery diarrhea among children under 5 years of age. Subjects and methods: This RCT trial included 50 children with acute watery diarrhea for 5 days or less with a frequency of three or more diarrheic stools in the past 24 hours before admission to the hospital, with no/mild to moderate dehydration.

Conditions

• Acute Watery Diarrhea

Interventions

Type	Name	Description
DRUG	Racecadotril	racecadotril (dose of 1.5 mg/kg/day, an oral single daily dose for three days

Timeline

• Start date: 2018-06-01
• Primary completion: 2018-07-31
• Completion: 2018-08-31
• First posted: 2022-02-01
• Last updated: 2022-02-01

Locations

1 site across 1 country: Egypt