Trials / Terminated
TerminatedNCT05215496
[18F]Fluoro-PEG-folate PET/CT Imaging in Epithelial Ovarian Cancer
- Status
- Terminated
- Phase
- Phase 1
- Study type
- Interventional
- Enrollment
- 5 (actual)
- Sponsor
- Lioe-Fee de Geus-Oei, MD PhD · Academic / Other
- Sex
- Female
- Age
- 30 Years
- Healthy volunteers
- Not accepted
Summary
The pre-operative assessment of intra-abdominal tumor load in patients with epithelial ovarian cancer (EOC) remains unreliable with standard imaging modalities. The use of tumor targeted imaging, such as folate receptor (FR)-targeted positron emission tomography (PET) imaging could aid in the preoperative assessment of metastatic tumor load. This study aims to evaluate the safety and tolerability, and pharmacokinetics of the \[18F\]fluoro-PEG-folate PET tracer and to assess the sensitivity and specificity of a \[18F\]fluoro-PEG-folate PET/CT scan for the preoperative detection of intra-abdominal metastatic lesions in patients with advanced stage epithelial ovarian cancer.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | [18F]fluoro-PEG-folate PET/CT scan | A dynamic FR-targeted PET scan, a low-dose CT scan without contrast agents, and a static FR-targeted PET scan will be obtained |
Timeline
- Start date
- 2022-05-10
- Primary completion
- 2023-05-01
- Completion
- 2023-05-01
- First posted
- 2022-01-31
- Last updated
- 2024-03-15
Locations
1 site across 1 country: Netherlands
Source: ClinicalTrials.gov record NCT05215496. Inclusion in this directory is not an endorsement.