NCT05210764

General Anesthetics-related Changes in Prefrontal EEG During Pediatric Surgical Anesthesia

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 366 (estimated)
• Sponsor: Peking University First Hospital · Academic / Other
• Sex: All
• Age: 1 Minute – 18 Years
• Healthy volunteers: Not accepted

Summary

The change profiles of indices derived from pEEG such as phase-amplitude coupling and bicoherence based on individual general anesthetics in children have not been examined in previous literature. Whether those indices have the abilities to predict individual drug-related anesthesia depth in children need to be explored.

Detailed description

The need to maintain a proper depth of general anesthesia during pediatric surgery is an important aspect of anesthesiology. An inappropriate anesthesia depth increases the risk of intraoperative awareness or delay in recovery in children undergoing surgery. Current modalities for anesthesia depth monitoring showed limited accuracy in children. The electroencephalogram (EEG) can be analyzed in its raw form for characteristic drug-induced patterns of change or summarized using mathematical parameters as a processed electroencephalogram (pEEG). The change profiles of indices derived from pEEG such as phase-amplitude coupling and bicoherence based on individual general anesthetics in children have not been examined in previous literature. Whether those indices have the abilities to predict individual drug-related anesthesia depth in children need to be explored.

Conditions

• General Anesthetic
• Electroencephalogram

Interventions

Type	Name	Description
DRUG	propofol	General anesthesia is induced and maintained mainly with propofol.
DRUG	sevoflurane	General anesthesia is induced and maintained mainly with sevoflurane.
DRUG	S-ketamine	General anesthesia is induced mainly with S-ketamine and maintained mainly with propofol.

Timeline

• Start date: 2022-06-01
• Primary completion: 2026-03-01
• Completion: 2026-08-01
• First posted: 2022-01-27
• Last updated: 2025-07-31

Locations

1 site across 1 country: China